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KMID : 0605620160230010018
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Journal of Korean Society of Biological Psychiatry
2016 Volume.23 No. 1 p.18 ~ p.23
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Mammalian Target of Rapamycin Signaling Pathways and Depression
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이정구:Lee Jung-Goo
서미경:Seo Mi-Kyoung/박성우:Park Sung-Woo/김영훈:Kim Young-Hoon
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Abstract
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Depression is a complicated psychiatric illness with severe consequences. Despite recent advanced achievements of molecular neurobiology, pathophysiology of depression has not been well elucidated. Among new findings of pathophysiology of depression, the possible fast antidepressant effect by N-methyl-D-asparate receptor antagonist, such as ketamine, is regarded as a promising treatment target of depression. Ketamine stimulates the mammalian target of rapamycin (mTOR) signaling pathway and activation of mTOR signaling pathway may be a key mechanism of the antidepressant effect of ketamine. Thus, this review describes the role of mTOR signaling in the pathophysiology of depression and developing a new treatment target of depression.
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KEYWORD
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Depression, Mammalian target of rapamycin, N-methyl-D-asparate receptor, Ketamine, Pathophysiology
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